Controlled drug release capability of paclitaxel-loaded poly(butylcyanoacrylate)-pluronic P123/F68 polymeric micells

doi:10.3969/j.issn.2095-4344.2013.16.012

Abstract

Abstract:

BACKGROUND: Paclitaxel-loaded poly(butylcyanoacrylate)-pluronic P123 polymeric micells can effectively prolong drug circulation time, and change the paclitaxel targets. However, the stability in solution and drug loading capacity of this kind of paclitaxel polymer micelles need to be improved.
OBJECTIVE: To investigate the pharmaceutical characteristics and antitumor ability of paclitaxel-loaded poly(butylcyanoacrylate)-pluronic P123/F68 polymeric micells.
METHODS: We prepared the paclitaxel-loaded poly(butylcyanoacrylate)-pluronic P123/F68 polymeric micells using the method of film dispersion and studied their characteristics, such as morphology, size, zeta potential, encapsulation efficiency, drug loading, the critical micelle concentration, drug release, micelle stability and cytotoxity in vitro.
RESULTS AND CONCLUSION: The morphology of the prepared micells was spherical with the mean size of 100 nm and the zeta potential of -10 mV. The mean encapsulation efficiency and drug loading were (93.3±2.15)% and (1.82±0.04)%, respectively. The critical micelle concentration was 0.067 g/L. The in vitro release and stability experiments showed that the micells exhibited controlled release ability and good stability. The paclitaxel-loaded poly(butylcyanoacrylate)-pluronic P123/F68 polymeric micells were apparently more potent in killing MCF-7 cells than the free drug. Therefore, paclitaxel-loaded poly(butylcyanoacrylate)-pluronic P123/F68 polymeric micells with good controlled release ability and stability may serve as nanoscopic and long-circulating carriers for poorly water-soluble anticancer drugs.

Key words: biomaterials, biomaterials and controlled drug release, paclitaxel, stablized micelles, long cycle, poly(butylcyanoacrylate), cytotoxicity, tumor, characterization, biocompatibility, International S&T Cooperation Program of China

CLC Number:

R318

Zhang Yang-de, Xu Hong-juan, Liang Jian, Wang Ji-wei, Pan Yi-feng, Deng Xin. Controlled drug release capability of paclitaxel-loaded poly(butylcyanoacrylate)-pluronic P123/F68 polymeric micells[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(16): 2935-2942.

Figures/Tables 7

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